The purpose of this research is to develop a model of causal factors affecting talent management and organizational commitment of medical personnel in Thailand in both the public and private sectors. The researcher applied the mixed methods research: consisting of quantitative research and qualitative research. Regarding the quantitative research, the samples were 520 medical personnel in Thailand in both the public and private sectors. Regarding the qualitative research, the researcher used the purposive sampling to define 5 key informants and another 5 experts for confirming the model. With regard to the analysis results of structural equation model according to the hypotheses, the adjusted structural equation model had all six goodness of fit indices that passed the acceptance criteria: χ2 /df = 1.020, CFI = 1.000, GFI = 0.973, AGFI = 0.954, RMSEA = 0.006 and RMR = 0.007. It can be concluded that the structural equation model had a good fit with the empirical data.